Fig. 14 | Cellular & Molecular Immunology

Fig. 14

From: Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns

Fig. 14The alternative text for this image may have been generated using AI.

The MxA inflammasome. Myxovirus resistance protein A (MxA) contains a dynamin-type GTPase domain, a middle domain, and a GTPase effector domain that forms a stalk-like structure. During influenza A virus infection, the GTPase domain of MxA binds to the pyrin domain of an apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), promoting inflammasome activation

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