Fig. 9 | Cellular & Molecular Immunology

Fig. 9

From: Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns

Fig. 9The alternative text for this image may have been generated using AI.

NAIP-NLRC4 inflammasome. The NAIP–NLRC4 inflammasome is activated by bacterial flagellin and components of the type III secretion system (T3SS). In mice, distinct NAIP proteins recognize flagellin, needle, and rod proteins, whereas in humans, a single NAIP protein detects all these ligands. Phosphorylation of NLRC4 by the protein kinase PKCδ and leucine-rich repeat kinase 2 (LRRK2) promotes NAIP–NLRC4 complex formation and the recruitment of caspase-1, with or without ASC, to assemble the inflammasome

Back to article page