Fig. 2: CD8+ T-cell subsets and their differentiation trajectories in the hematomas and peripheral blood of ICH patients. | Cellular & Molecular Immunology

Fig. 2: CD8+ T-cell subsets and their differentiation trajectories in the hematomas and peripheral blood of ICH patients.

From: FOXO1-driven metabolic reprogramming of hematomal CD8+ T cells drives the expansion of perihematomal edema following intracerebral hemorrhage

Fig. 2: CD8+ T-cell subsets and their differentiation trajectories in the hematomas and peripheral blood of ICH patients.

A UMAP of CD8+ T cells reclustered into 4 subpopulations: CD8_SELL, CD8_GZMK, CD8_GNLY and CD8_SLC4A10. B Bar plots showing the proportions of CD8+ T-cell subpopulations in the indicated groups of subjects. C Differential expression analysis comparing each cluster to others revealed distinct gene expression profiles, and the top genes from each cluster are displayed with gene names annotated on the right. D Trajectory of 4 clusters along pseudotime defined by Monocle2 in the indicated groups of subjects. E Heatmap showing differentially expressed genes during the trajectory and enriched GO terms for gene sets are represented on the right. F Averaged expression patterns of gene sets of interest along pseudotime

Back to article page