Fig. 1 | NPG Asia Materials

Fig. 1

From: Amphiphilic dendrimer engineered nanocarrier systems for co-delivery of siRNA and paclitaxel to matrix metalloproteinase-rich tumors for synergistic therapy

Fig. 1

a Schematic structure of typical PEG-PLA nanoparticles with drugs in the PLA core (left), an amphiphilic dendrimersome and its complex with siRNA (middle), and the three layer structure of the ADENS (right). b Representation of the MMP-2/9 response, internalization and intracellular transportation of TMSP-ADENS. The simultaneous delivery of siRNA and PTX in tumor cells is the basis for the optimal therapeutic efficacy of the combination strategy of siVEGF for anti-angiogenesis and PTX for cytotoxicity

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