Fig. 6

Cellular uptake of various FAM-siRNA-loaded ADENS in (a) HT-1080 and (c) PC-3 cells. b Cellular uptake of COU-loaded TMSP-ADENS in A375 cells in the presence of GM6001 (an MMP inhibitor) and activated MMPs at different concentrations ranging from 0.2 µg/mLto 20 µg/mL. All data are presented as the mean ± SD (n = 3). *P < 0.05; **P < 0.01; ***P < 0.001; NS not significant