Fig. 3: Sequential decomposition of CCM/IDINPs in tumor cells upon NIR laser and X-ray irradiation. | NPG Asia Materials

Fig. 3: Sequential decomposition of CCM/IDINPs in tumor cells upon NIR laser and X-ray irradiation.

From: Bioinspired tumor-homing nanosystem for precise cancer therapy via reprogramming of tumor-associated macrophages

Fig. 3: Sequential decomposition of CCM/IDINPs in tumor cells upon NIR laser and X-ray irradiation.

Schematic illustration (a) and TEM images (b) of CCM/IDINPs after the treatments of Phase I: GSH (20 μM) at pH 7.4, Phase II: GSH (20 μM) at pH 6.8, Phase III: GSH (10 mM) at pH 7.4, Phase IV: Laser + GSH (10 mM) at pH 7.4, and Phase V: Laser + X-ray + GSH (10 mM) at pH 7.4, scale bar = 50 nm. c Sequential release rate of DOX from CCM/IDINPs at Phase I-V. **P < 0.01 between Phase I and Phase V at 120 h. The data are presented as the means ± SD; n = 3. d The intracellular localization of CCM/IDINPs in MG-63 cells after 12 h. The cytoskeleton was labeled with Alexa Fluor 488 phalloidin (green fluorescence). The nucleus was labeled with Hoechst 33342 (blue fluorescence). The intracellular localization of CCM/IDINPs was recorded by monitoring the red fluorescence of DOX; scale bar = 10 μm

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