Fig. 1: Schematic introduction of the nanodiamond/polycaprolactone (ND/PCL) nerve bridge manufacturing process and in vivo performance. | NPG Asia Materials

Fig. 1: Schematic introduction of the nanodiamond/polycaprolactone (ND/PCL) nerve bridge manufacturing process and in vivo performance.

From: Multilayered spraying and gradient dotting of nanodiamond–polycaprolactone guidance channels for restoration of immune homeostasis

Fig. 1

A tubular mold was placed horizontally with a roller rotating counterclockwise. The multi-injector nozzle sprayed the ND/PCL mixed solution vertically toward the tubular mold. Micropores were created on the ND/PCL layer. After the first layer was solid, the nozzle sprayed the second ND/PCL layer onto the first layer. Staggered micropores were added to the second layer. Similarly, the third layer, which was also the outermost layer, was sprayed on the previous two layers. The concentric triple-layered structure provided appropriate elasticity and receptivity. In addition, this structure regenerated peripheral nerves and induced macrophage polarization in vivo. The yellow arrow refers to the components

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