Fig. 4: Morphological recovery of sciatic nerves from the nanodiamond/polycaprolactone (ND/PCL), PCL, and autograft groups. | NPG Asia Materials

Fig. 4: Morphological recovery of sciatic nerves from the nanodiamond/polycaprolactone (ND/PCL), PCL, and autograft groups.

From: Multilayered spraying and gradient dotting of nanodiamond–polycaprolactone guidance channels for restoration of immune homeostasis

Fig. 4

Regenerated sciatic nerve morphology using hematoxylin–eosin (a–c) and toluidine blue (d–f) staining at 4 months postoperatively. ND/PCL nerve bridge (a, d). PCL nerve bridge (b, e). Autograft (c, f). Scale bar = 100 μm. Axon regrowth and remyelination evaluation of regenerated sciatic nerves using transmission electron microscopy at 4 months postoperatively. ND/PCL nerve bridge (g–i). PCL nerve bridge (j–l). Autograft (m–o). Scale bars: 10 μm (g, j, m); 2 μm (h, k, n); 1 μm (i, l, o). Myelinated axon number (104) (p). Myelin sheath thickness (μm) (q). Regenerated axon area (mm2) (r). Average myelinated axon diameter (μm) (s). *p < 0.05 compared with autograft, #p < 0.05 compared with PCL

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