Fig. 12
From: Triple-synergistic 2D material-based dual-delivery antibiotic platform
Schematic illustration of the interaction between HAS and microorganisms a and the synergistic antibacterial mechanism of HAS b. The antibacterial mechanism could be divided into three parts (Fig. 12B): (1) The capping effect of graphene oxide via intermolecular forces has two antibacterial functions: (i) significantly enhancing the concentration of Ag NPs and SD around bacteria and (ii) blocking nutrient transport; (2) The puncture effect of Ag NPs; and (3) The inhibitory effect of SD, which could directly inhibit nucleic acid synthesis in bacterial cells and could weaken the E. coli cell wall. In this study, a novel hybrid antibacterial system (HAS) based on graphene oxide (GO) 2D materials for co-delivery of silver nanoparticles (Ag NPs) and sulfadiazine (SD) was fabricated. The antibacterial activity of HAS was enhanced over 3 times due to triple synergy: capping effect of GO, puncture effect of Ag NPs, and inhibitory effect of SD. This study provides new insights into the design and fabrication of antibiosis systems and multifunctional materials and broadens the biomedical applications of 2D materials.
