Fig. 2: Antimicrobial performance of a PEG–peptide complex. | NPG Asia Materials

Fig. 2: Antimicrobial performance of a PEG–peptide complex.

From: A molecular architectural design that promises potent antimicrobial activity against multidrug-resistant pathogens

Fig. 2: Antimicrobial performance of a PEG–peptide complex.The alternative text for this image may have been generated using AI.

a Conjugation route of the PEG12k–1*Mel complex. b Representative SEM images of E. coli and S. aureus bacteria after 16 h of exposure to native Mel, PEG12k–1*Mel (peptide concentration of 64 µg mL−1 (with respect to the peptide)), or no agent exposure. Arrows indicate lesions and collapses of the bacterial membrane. c MIC distributions of pure Mel and PEG12k–1*Mel against E. coli and S. aureus. P-values were calculated by ANOVA (**P < 0.01, ***P < 0.001). The insets depict the time-dynamic antimicrobial assays showing the effects of native Mel and PEG12k–1*Mel treatments (0, 3, 6, or 16 h) on bacterial viability before determining the colony-forming unit (CFU). d Standard Alamar blue cell proliferation assay of MGC-803 cells cultured with pure Mel or PEG12k–1*Mel for 24 h. The concentrations of the agents varied between 1.6 and 200.0 µg mL−1. The data show the normalized mean and standard error of at least three independent experiments. e Antimicrobial activities (MICs of other commercial antibiotics are shown in Table S1 of Supplementary Information).

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