Fig. 5: Effect of NP elasticity on the nano-bio interface interactions between NPs and the cell membrane. | NPG Asia Materials

Fig. 5: Effect of NP elasticity on the nano-bio interface interactions between NPs and the cell membrane.

From: Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application

Fig. 5: Effect of NP elasticity on the nano-bio interface interactions between NPs and the cell membrane.

a Computational models of elastic NP and membrane. b Snapshots for deformation of elastic NPs with different bending rigidities kb = 0.1ε, 1ε, 10ε, 100ε under different wrapping ratios f. Reproduced with permission35. Copyright 2018, Royal Society of Chemistry. c Molecular structures of computational models: PEGylated rigid NP, PEGylated liposome, lipid, and PEG polymer models for both types of PEGylated NPs, and lipid membrane with receptors. d Phase diagram for the membrane wrapping of PEGylated rigid NPs and PEGylated liposomes under the influences of membrane lateral tension and PEG molar ratio. Reproduced with permission36. Copyright 2018, Royal Society of Chemistry.

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