Fig. 1: Anticancer drug-mediated assembly of siRNA-carrying DNA nanostructures for synergistically combating lung cancer. | NPG Asia Materials

Fig. 1: Anticancer drug-mediated assembly of siRNA-carrying DNA nanostructures for synergistically combating lung cancer.

From: Assembling defined DNA nanostructures with anticancer drugs: a metformin/DNA complex nanoplatform with a synergistic antitumor effect for KRAS-mutated lung cancer therapy

Fig. 1

A Schematic illustration of the metformin-induced, magnesium-free self-assembly of tile-based and DNA origami nanostructures. B Metformin (MF), an anticancer drug, embedded together with KRASG12C siRNA in DNA nanostructures, exhibited a synergistic anticancer effect both in vitro and in a xenograft mouse model of KRASG12C-mutated NSCLC. NTMFK refers to KRASG12C siRNA-loaded DNA nanotubes (tile-based) assembled with metformin.

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