Fig. 4: Recording of SE states in a free-moving rat using a hybrid graphene multichannel electrode.
From: Hybrid graphene electrode for the diagnosis and treatment of epilepsy in free-moving animal models
a Photograph (top) and topographical design (bottom) of a hybrid graphene electrode. b Behavioral monitoring of SE stages according to Racine’s scale after successive injection of 10 mg/kg of pilocarpine every 30 min (top), and a timeline of sequential experiments from hybrid graphene electrode implantation to induction of SE state (bottom). c Representative electrocorticograms at each behavior state: normal state (stage 0), motionless staring and orofacial automatism (stage 1), nodding (stage 2), forelimb clonus (stage 3), rearing and falling (stage 4), and generalized seizure (stage 5). The hybrid graphene electrode array allows concurrent observation of neural activities and behavioral changes in awake, free-moving animals.
