Fig. 4: Regulating lipid membranes with DNA origami structures. | NPG Asia Materials

Fig. 4: Regulating lipid membranes with DNA origami structures.

From: Fabricating higher-order functional DNA origami structures to reveal biological processes at multiple scales

Fig. 4

a Frame-guided assembly of amphiphilic molecules on DNA origami nanosheets. (Reproduced with permission136, Copyright 2016, Wiley-VCH). b Synthesis of size-controlled liposomes with DNA origami templates. c Vesicle tubulation controlled by the DNA origami nanosprings. DNA origami monomers are absorbed onto the vesicle with the help of amphipathic peptides and polymerized into nanosprings via linker strands, which can shape vesicles into tubules. (Reproduced with permission143, Copyright 2018, Wiley-VCH). d A synthetic lipid membrane channel created with a DNA origami structure inserted into a lipid membrane via cholesterol moieties. (Reproduced with permission145, Copyright 2012, AAAS). e A synthetic DNA origami channel equipped with a size-selective gating system for the transport of macromolecules. (Reproduced with permission150, Copyright 2019, Macmillan Publishing Ltd.). f A DNA origami-SNARE hybrid platform for exploring the membrane-fusion process. (Reproduced with permission153, Copyright 2016, American Chemical Society).

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