Fig. 6: DNA origami-based smart drug delivery systems. | NPG Asia Materials

Fig. 6: DNA origami-based smart drug delivery systems.

From: Fabricating higher-order functional DNA origami structures to reveal biological processes at multiple scales

Fig. 6

a The E. coli and B. subtilis bacterial strain-targeted aptamer-functionalized DNA origami nanocarriers for antimicrobial delivery. (Reproduced with permission181, Copyright 2020, Wiley-VCH). b A reconfigurable DNA origami nanocapsule for pH-controlled encapsulation and display of cargo molecules. The pH-responsive latches are DNA triplexes that form at low pH and disassemble at high pH. (Reproduced with permission111, Copyright 2019, American Chemical Society). c A DNA nanorobot for triggered cargo exposure based on AND logic. The sequestered antibody fragments are exposed for cell signaling regulation when both aptamer-based locks are attached to the targeted cell surface markers. (Reproduced with permission189, Copyright 2012, AAAS). d A tubular DNA nanorobot for siRNA/chemo-drug codelivery. TAT peptides are attached to the outer surface of the nanorobot to improve cellular uptake and tumor retention. DNA locks containing disulfide bonds are used to seal the nanotube and release the siRNA cargos upon interacting with glutathione in the cytoplasm. (Reproduced with permission193, Copyright 2021, Wiley-VCH).

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