Table 1 Comparisons among nonsurgical and surgical approaches for bone repair.

From: Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration

Categories

Approach

Medium

Advantages

Disadvantages

Nonsurgical approaches

Casting

Plaster or fiberglass

Easy availability and effectiveness

Potential muscle atrophy and stiffness

Electrical stimulation

Electricity and magnetism

Safety

Assistive technology

Ultrasound therapy

Sound waves

Convenience

Skin irritation or mild pain; assistive technology

Surgical approaches

Internal fixation

Metal screws, plates, or rods

Ability to enable early mobilization and weight-bearing activities

Potential for infection, implant failure, and nerve damage; low pain and swelling

External fixation

Metal pins or screws

Stable fixation

Potential for infection, pin loosening, and pin tract infection

Bone grafting

Bone tissue and metal pins or screws

Rapid recovery

Potential for graft rejection

Bone regeneration

Biological agents; scaffolds or matrices

Abundant materials with different functions

Potential for infection, inflammation, and rejection of the biologic agents or scaffolds