Fig. 3: In Vitro and In Vivo Biocompatibility of the GORoM Hydrogel.
From: A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis
A Live/Dead staining of BMSCs after 24 h of coculture with different hydrogels. Live cells are marked with green fluorescence, and dead cells are marked with red fluorescence (scale bar: 200 μm). B CCK-8 assay results for BMSCs cultured on the hydrogels for 1, 3, and 7 days. C Cytoskeletal staining photos of cells cultured on the hydrogel after 2 days (scale bar: 50 μm). D Pathological images of the heart, liver, kidney, and lung of mice in each group (scale bar: 50 μm). E Serum levels of biomarkers reflecting liver and kidney function and blood cell parameters in the rats treated with the GORoM hydrogel (n = 3). *p < 0.05, **p < 0.01, and ***p < 0.001.
