Abstract
Four new compounds, phomalichenones A–D (1–4), and seven known compounds (5–11) were isolated from the cultures of an endolichenic fungus Phoma sp. EL002650. Their structures were determined by the analysis of their spectroscopic data (NMR and MS). Compounds 1 and 6 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In addition, compound 1 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin(IL)-1β, and IL-6.
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Acknowledgements
This work was supported by the International Joint Research Project (ASIA-16-011) of the NST (National Research Council of Science & Technology), Young Researcher Program (NRF-2017R1C1B2002602) of the NRF (National Research Foundation of Korea), and KRIBB Research Initiative Program funded by the Ministry of Science ICT (MSIT) of Republic of Korea. We thank the Korea Basic Science Institute, Ochang Korea, for providing the NMR (700 MHz) and HRESIMS data.
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Kim, J.W., Ko, W., Kim, E. et al. Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp.. J Antibiot 71, 753–756 (2018). https://doi.org/10.1038/s41429-018-0058-7
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DOI: https://doi.org/10.1038/s41429-018-0058-7
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