Table 1 Antibacterial activity of amSPC compounds
From: Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens
MIC (µg ml-1) | ||||||
|---|---|---|---|---|---|---|
Pathogen | 1950 | 1951 | 2241 | 2324 | SPTa | |
B. mallei | MIC Rangeb | 3.13–50 | 3.13–50 | 3.13–50 | 1.56–50 | 8–16 |
MIC50 | 6.3 | 6.3 | 6.3 | 6.3 | 8 | |
MIC90 | 12.5 | 12.5 | 12.5 | 12.5 | 16 | |
Brucella spp.c | MIC Rangeb | 0.4–12.5 | 0.4–12.5 | 0.4–12.5 | ≤0.2–6.3 | 1–32 |
MIC50 | 1.56 | 3.13 | 1.56 | 1.56 | 4 | |
MIC90 | 3.13 | 6.25 | 3.13 | 6.25 | 8 | |
F. tularensis | MIC Rangeb | 1.56–200 | 3.13–200 | 3.13–200 | 1.56–200 | 1->64 |
MIC50 | 12.5 | 6.25 | 12.5 | 6.25 | 64 | |
MIC90 | 100 | 50 | 50 | 50 | >64 | |
B. anthracis | MIC Rangeb | 12.5–100 | 6.25–50 | 3.13–25 | 12.5–50 | 16->64 |
MIC50 | 25 | 25 | 12.5 | 25 | 64 | |
MIC90 | 50 | 50 | 12.5 | 25 | 64 | |
Y. pestis CO92 | MIC | 50 | 50 | 25 | 50 | 32 |
B. pseudomallei d | MIC | >200 | >200 | >200 | >200 | >64 |
