Table 3 MIC of active inverted pantothenamides on multiple strains
From: Stable pantothenamide bioisosteres: novel antibiotics for Gram-positive bacteria
Compound | S.aureus ATCC6538 | S.aureus ATCC29213 | S.aureus MRSA | S.aureus Xen36 | S.epidermidis ATCC12228 | S.epidermidis Bactimm 389 | S.epidermidis ATCC14990 | S.pyogenes SS91 | S.pyogenes SS410 | S.pyogenes SS799 |
|---|---|---|---|---|---|---|---|---|---|---|
CXP18.6–012 | 2 | 2 | 8 | 4 | 8 | 4 | 4 | 32 | >32 | >32 |
CXP18.6–013 | 32 | >32 | >32 | 16 | 16 | >32 | 16 | 2 | 2 | 2 |
CXP18.6–014 | 4 | 2 | 4 | 8 | 2 | 2 | 2 | 32 | 32 | >32 |
CXP18.6–017 | 2 | 1 | 2 | 2 | 2 | 2 | 4 | >32 | >32 | >32 |
CXP18.6–069 | 8 | 2 | 4 | 8 | 1 | 2 | 1 | >32 | >32 | >32 |
CXP18.6–047 | 16 | 32 | 32 | 8 | 16 | 16 | 8 | 8 | 16 | 16 |
CXP18.6–057 | 16 | 16 | 32 | 8 | 8 | 16 | 8 | 4 | 8 | 4 |
CXP18.6–064 | 4 | 8 | 4 | 8 | 1 | 1 | 1 | >32 | >32 | >32 |
CXP14.18–028 | >32 | >32 | >32 | >32 | >32 | 16 | 8 | 2 | 2 | 2 |
CXP14.18–005 | >32 | >32 | >32 | >32 | >32 | 32 | 8 | 8 | 2 | 4 |
CXP14.26–007 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 8 | 8 | 8 |
CXP14.18–037 | >32 | >32 | >32 | 32 | 32 | >32 | 16 | 4 | 2 | 2 |
CXP14.18–038 | >32 | >32 | >32 | >32 | >32 | >32 | 32 | 8 | 4 | 8 |
CXP14.18–034 | >32 | 32 | >32 | 16 | >32 | 32 | 8 | 8 | 4 | 8 |
CXP14.18–012 | >32 | 8 | 32 | 32 | 2 | 4 | 2 | 16 | 8 | 16 |
