Abstract
Endoplasmic reticulum (ER) stress and the subsequent adaptive cellular response, termed the unfolded protein response (UPR), have been implicated in several diseases, including cancer. In this review, I present a brief introduction to ER stress and the UPR and then summarize the importance of the IRE1α-XBP1 branch as a target for anticancer drug discovery. In addition, I introduce our approach to the identification of inhibitors against the IRE1α-XBP1 branch from microbial cultures. As a result of our screening, toyocamycin has been identified and toyocamycin showed anticancer activity against multiple myeloma.
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Acknowledgements
We wish to thank all past and present colleagues whose names are cited in the references for their contributions. We are especially grateful to Prof. M Imoto for the fruitful discussion.
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Tashiro, E. Screening and identification of inhibitors of endoplasmic reticulum stress-induced activation of the IRE1α-XBP1 branch. J Antibiot 72, 899–905 (2019). https://doi.org/10.1038/s41429-019-0219-3
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DOI: https://doi.org/10.1038/s41429-019-0219-3
