Table 1 Characteristics of each structure and activity in liposidomycin, caprazamycin, A90289A, and muraminomycin

From: Liposidomycin, the first reported nucleoside antibiotic inhibitor of peptidoglycan biosynthesis translocase I: The discovery of liposidomycin and related compounds with a perspective on their application to new antibiotics

 

Sulfate group

3-Methyl glutaric acid group

Permethylated l-rhamnose group

PG inhibition

Antimicrobial activity

Cytotoxicity

Liposidomycin I type (original)

○

○

×

〇

×

×

Liposidomycin II type

○

○

×

〇

×

×

Liposidomycin III type

×

○

×

〇

〇

×

Liposidomycin IV type

×

×

×

〇

〇

×

Caprazamycin

×

○

○

―

―

―

A-90289A

○

○

○

―

―

―

Muraminomycin

×

○

△

―

―

―

  1. △: with succinic acid, ―: not determined in the assay
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