Table 1 Antibacterial susceptibility (MIC, μg ml−1) and ribosomal affinity IC50 (μg ml−1) studies of synthesized compounds
From: Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins
Compounds | M. tuberculosis H37Rv MIC (µg ml−1) | S. pneumoniae R6 MIC (μg ml−1) | E. coli K-12 MIC (µg ml−1) | E. coli cellular accumulation (µM) | Ribosome translation inhibition IC50 (μg ml−1) |
|---|---|---|---|---|---|
Spectinomycin (1) | 50 | 12.5 | 25 | 1.1 ± 0.1 | 0.36 |
2 | 1.6 | 12.5 | 200 | 5.4 ± 0.8 | 0.89 |
3 | 6.25 | 3.13 | 50 | 40 + 1 | 0.74 |
4 | 1.6 | 12.5 | 100 | 5.9 + 0.8 | 0.84 |
5 | >200 | >200 | >200 | 2.3 + 0.4 | >60 |
6 | 50 | 25 | >200 | 10.0 + 0.6 | 9.50 |
7 | 100 | 25 | >200 | 47 + 1 | 23.3 |
8 | >200 | >200 | >200 | 1.29 ± 0.06 | 54.7 |
9 | >200 | >200 | >200 | <0.4 | >60 |
10 | 200 | 50 | >200 | 5.6 ± 0.5 | 10.2 |
11 | 100 | >200 | >200 | 1.77 ± 0.06 | 34.7 |
