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Induced production of a new antioxidant phenylpropanoid from Streptomyces sp. by protoplast formation/regeneration

The Journal of Antibiotics volume 75, pages 698–701 (2022)Cite this article

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Abstract

Streptomyces sp. RD007556 regenerated from protoplast was found to produce p-coumaric acid 3,4-dihydroxybenzoate, propla acid (1) which is not observed in the wild-type strain. The structure of 1 was determined by NMR and MS analyses. Compound 1 showed antioxidant activities in DPPH and superoxide dismutase-like assays.

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Acknowledgements

P388 cells were obtained from JCRB Cell Bank under accession code JCRB0017 (Lot. 06252002).

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  1. Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan

    Enjuro Harunari, Nodoka Yago & Yasuhiro Igarashi

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  1. Enjuro Harunari
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  2. Nodoka Yago
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  3. Yasuhiro Igarashi
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Correspondence to Yasuhiro Igarashi.

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Harunari, E., Yago, N. & Igarashi, Y. Induced production of a new antioxidant phenylpropanoid from Streptomyces sp. by protoplast formation/regeneration. J Antibiot 75, 698–701 (2022). https://doi.org/10.1038/s41429-022-00570-2

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