Table 1 Cellular activity of rifampicin-based antibiotics

From: Potent Rifampicin derivatives can clear MRSA infections at single low doses when concomitantly dosed with Vancomycin

  

S. aureus NRS384

Salmonella typhimurium AR-0031

Salmonella typhimurium ATCC 14028

No.

Structure

Broth MIC (M)

Intracellular MIC (M)

Broth MIC (M)

Intracellular MIC (M)

Broth MIC (M)

Intracellular MIC (M)

1

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1.56E−08

1.00E−06

1.60E−05

No activity

1.60E−05

No activity

2

4.12E−07

1.00E−06

    

3

4.57E−08

1.00E−06

    

4

3.91E−09

4.00E−08

1.00E−06

3.00E−05

4.00E−06

1.00E−04

5

3.91E−09

4.00E−08

1.00E−06

3.00E−05

4.00E−06

>1e−4

6

6.25E−08

1.00E−06