Table 5 Rat toxicity study design for once-a-day (QD) dosing of compounds 4 and 5
Group Number | Treatment | Dose Level (mg/kg/day) | Dose volume (mL/kg) | Dose concentration (mg/mL) | Tox Group (Main/Recovery) | |
|---|---|---|---|---|---|---|
Males | Females | |||||
1 | Vehicle 1 (Compound 4) | 0 | 5 | 0 | 5/3 | -- |
2 | Vehicle 2 (Compound 5) | 0 | 5 | 0 | 5/3 | -- |
3 | Rifampicin | 25 | 5 | 5 | 5/3 | -- |
4 | Vancomycin | 110 | 5 | 22 | 5/3 | -- |
5 | Compound 4 | 0.1 | 5 | 0.02 | 5/3 | -- |
6 | Compound 4 | 1 | 5 | 0.2 | 5/3 | 5/3 |
7 | Compound 4 | 10 | 5 | 2 | 5/3 | -- |
8 | Compound 4 + vancomycin | 1 + 110 | 2.5; 2.5 | 0.4; 44 | 5/3 | -- |
9 | Compound 5 | 0.1 | 5 | 0.02 | 5/3 | -- |
10 | Compound 5 | 1 | 5 | 0.2 | 5/3 | 5/3 |
11 | Compound 5 | 10 | 5 | 2 | 5/3 | -- |
12 | Compound 5 + vancomycin | 1 + 110 | 2.5; 2.5 | 0.4; 44 | 5/3 | -- |
