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Cytotoxic glutarimide-containing polyketides isolated from Streptomyces sp. JCM 4793

The Journal of Antibiotics volume 77, pages 627–633 (2024)Cite this article

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Abstract

Glutarimide-containing polyketides usually exhibit anti-fungi activity, which was well exampled by cycloheximide. In our work, three new polyketide structures, 12-amidestreptimidone (1), 12-carboxylstreptimidone (2) and 3-(5S,8R)-(2-amino-2-oxoethyl-2’-methoxy-2’-oxoethyl)-8,10-dimethyl-7-oxododeca-5-hydroxy-9E,11-diolefin (3) were isolated from Streptomyces sp. JCM 4793. 3 without the glutarimide moiety is not active against fungi as expected, while 1 bearing the amide moiety is much more active than its carboxylic form 2. Here we report the isolation, structural elucidation, antifungal activity, and proposed biosynthesis pathway of 1–3.

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Acknowledgements

This research was supported financially by grants from the National Science Foundation of China (22177050), the Xingdian Talent Support Program of Yunnan Province (XDYC-QNRC-2022-0774), Yunnan Provincial Science and Technology Department (202301AT070323), and Youth Innovation Promotion Association CAS to (2022395).

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Author notes

  1. These authors contributed equally: Mingming Cao, Yi Zhao, Yan-Yun Che

Authors and Affiliations

  1. Faculty of Pharmacy, Yunnan University of TCM, Kunming, Yunnan, 650500, China

    Lin-Fang Tang, Wu-Lai Jihuo, Zi-Kang Zhao, Yi Zhao & Yan-Yun Che

  2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China

    Lin-Fang Tang, Wu-Lai Jihuo, Pei-Dong Shi, Cui-Xuan Mei, Zi-Kang Zhao, Yuan Chen, Ying-Tong Di, Xiao‑Jiang Hao & Mingming Cao

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  1. Lin-Fang Tang
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Correspondence to Mingming Cao, Yi Zhao or Yan-Yun Che.

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Tang, LF., Jihuo, WL., Shi, PD. et al. Cytotoxic glutarimide-containing polyketides isolated from Streptomyces sp. JCM 4793. J Antibiot 77, 627–633 (2024). https://doi.org/10.1038/s41429-024-00743-1

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