Table 2 Bioassay results for compounds 1–6 and 8
From: Geministatins: new depside antibiotics from the fungus Austroacremonium gemini
Compound | Minimum inhibitory concentration (MIC; µg mL–1) | IC50 (µM) | ||||
|---|---|---|---|---|---|---|
B. subtilis | S. aureus | MRSA | S. cerevisiae | NS-1 | NFF | |
1 | 1.6 | 6.3 | 6.3 | >200 | 71 | >140 |
2 | 0.39 | 3.1 | 1.6 | >200 | 93 | >190 |
3 | >100 | >100 | >100 | >200 | 17 | 19 |
4 | 25 | >100 | >100 | 13 | 68 | >180 |
5 | 13 | >100 | 50 | >200 | 8.7 | 47 |
6 | 0.2 | 3.1 | 0.78 | >200 | 64 | >260 |
8 | 25 | >100 | >100 | >200 | >590 | >590 |
Controlsa | 6.3 | 3.1 | >100 | 3.1 | 1.7 | 1.7 |
