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Cytosporones Y and Z, new antifungal polyketides produced by the fungal strain Trichoderma sp. FKI-6626

The Journal of Antibiotics volume 77, pages 721–726 (2024) Cite this article

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Abstract

Two new antifungal polyketides, named cytosporones Y (1) and Z (2), were discovered from the cultured broth of Trichoderma sp. FKI-6626. Their structures were elucidated by MS and NMR analysis. Both compounds exhibited antifungal activity against five Aspergillus species, the causative agents of aspergillosis.

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Acknowledgements

We are grateful to Distinguished Emeritus Professor Satoshi Ōmura (Kitasato University) for his helpful support and valuable guidance and suggestions. We thank Dr. Kenichiro Nagai, Ms. Reiko Seki, and Ms. Noriko Sato (School of Pharmacy, Kitasato University) for various instrumental analyses. This research was partially supported by Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number JP21am0101096 (Phase I) and JP22ama121035 (Phase II). This work was supported by the JSPS KAKENHI Grant (JP21K05293). This work was also supported by a Grant-in-Aid for Transformative Research Areas (A) “Latent Chemical Space” [JP23H04880 and JP23H04884] for MI from the Ministry of Education, Culture, Sports, Science and Technology, Japan. This study was partly supported by Joint Usage/Research Program of Medical Mycology Research Center, Chiba University (18–16, 19–10, and 21–25).

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Author notes

  1. These authors contributed equally: Haruki Azami, Yoshihiro Watanabe

Authors and Affiliations

  1. Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Haruki Azami, Yoshihiro Watanabe, Hiroki Kojima, Kenichi Nonaka & Masato Iwatsuki

  2. Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Yoshihiro Watanabe, Hiroki Kojima, Kenichi Nonaka & Masato Iwatsuki

  3. School of Science, Kitasato University, 1-15-1, Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan

    Yurika Yoshida

  4. Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8673, Japan

    Sayaka Ban & Takashi Yaguchi

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  1. Haruki Azami
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  2. Yoshihiro Watanabe
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Correspondence to Masato Iwatsuki.

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Azami, H., Watanabe, Y., Kojima, H. et al. Cytosporones Y and Z, new antifungal polyketides produced by the fungal strain Trichoderma sp. FKI-6626. J Antibiot 77, 721–726 (2024). https://doi.org/10.1038/s41429-024-00765-9

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