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New amino-naphthoic acid derivatives produced by biological transformation using the deep-sea-derived bacterium Serinicoccus marinus KDM482

The Journal of Antibiotics volume 78, pages 573–576 (2025)Cite this article

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Abstract

Deep-sea-derived microorganisms are quite attractive as resources for new secondary metabolites, enzymes, and gene discovery. We have isolated many marine microorganisms from deep-sea creatures and screened the new secondary metabolites produced by them. Two new molecules designated amino-naphthoic acid derivatives (1 and 2) were obtained by biological transformation using the deep-sea derived bacterium Serinicoccus marinus KDM482 successfully. Structural analysis using 1D and 2D NMR and MS data revealed that both 1 and 2 were dimerized compounds of 3-amino-2-naphthoic acid. In biological assays, 1 and 2 moderately inhibited the growth of Malme-3M cells.

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Acknowledgements

We thank Ms. Saori Aoyama for supplying the deep-sea creatures. This work was supported by the Grant for Scientific Research from the Agriculture Technology and Innovation Research Institute, Kindai University.

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Authors and Affiliations

  1. Department of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan

    Mai Sakaguchi, Katsuki Kikuchi, Ryota Okamura, Akito Taniguchi, Masashi Ando, Teruyoshi Tanaka & Takashi Fukuda

  2. Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan

    Kenichiro Nagai & Reiko Seki

  3. Agricultural Technology and Innovation Research Institute, Kindai University, Nara, Japan

    Takashi Fukuda

Authors
  1. Mai Sakaguchi
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  2. Katsuki Kikuchi
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Correspondence to Takashi Fukuda.

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Sakaguchi, M., Kikuchi, K., Okamura, R. et al. New amino-naphthoic acid derivatives produced by biological transformation using the deep-sea-derived bacterium Serinicoccus marinus KDM482. J Antibiot 78, 573–576 (2025). https://doi.org/10.1038/s41429-025-00845-4

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