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Marinapyrones A and B, new antioxidative α-pyrones produced by soybean rhizosphere-derived actinomycete strain W21-0103

The Journal of Antibiotics (2026)Cite this article

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Abstract

Two new α-pyrone compounds designated marinapyrones A (1) and B (2) were isolated along with the known related compound micropyrone B (3) from the culture broth of rhizosphere-derived actinomycete strain W21-0103. The structures of 1 and 2 were elucidated by spectroscopic data analyses, including 1D and 2D NMR. Compounds 1-3 exhibited weak antioxidant activity in a radical scavenging assay.

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Acknowledgements

We express our thanks to Dr. Kenichiro Nagai, Ms. Reiko Seki, and Ms. Noriko Sato at the School of Pharmacy, Kitasato University for instrumental measurements and Ms. Fuka Arai, Ms. Yuna Kido, Ms. Sarasa Sakagami, and Ms. Misaki Sato at the School of Pharmacy, Kitasato University for assisting with our experiments. This work was supported by a Kitasato University Research Grant for Young Researchers (to SS). This work was partially supported by Cabinet Office, Government of Japan, Moonshot R&D Program for Agriculture, Forestry and Fisheries (JPJ009237, funding agency: Biooriented Technology Research Advancement Institution) (to H Takeyama).

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Authors and Affiliations

  1. Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan

    Satoru Shigeno, Hiroshi Tomoda & Taichi Ohshiro

  2. Medicinal Research Laboratories, School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan

    Satoru Shigeno, Hiroshi Tomoda & Taichi Ohshiro

  3. Research Organization for Nano and Life Innovation, Waseda University, Shinjuku-Ku, Tokyo, Japan

    Yuki Onishi, Yohei Nishikawa, Takuji Nakashima & Haruko Takeyama

  4. Biomanufacturing and Process Research Center, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan

    Yohei Nishikawa

  5. Department of Field Sciences, University of Human Environment, Matsuyama-Shi, Ehime, Japan

    Takuji Nakashima

Authors
  1. Satoru Shigeno
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  2. Yuki Onishi
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  3. Yohei Nishikawa
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  4. Takuji Nakashima
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  5. Haruko Takeyama
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  6. Hiroshi Tomoda
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  7. Taichi Ohshiro
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Correspondence to Taichi Ohshiro.

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41429_2026_898_MOESM1_ESM.docx

SI_Marinapyrones A and B, new antioxidative XX-pyrones produced by soybean rhizosphere-derived actinomycete strain W21-0103

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Shigeno, S., Onishi, Y., Nishikawa, Y. et al. Marinapyrones A and B, new antioxidative α-pyrones produced by soybean rhizosphere-derived actinomycete strain W21-0103. J Antibiot (2026). https://doi.org/10.1038/s41429-026-00898-z

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