Table 3 Association of COPD with DNA methylation at 10 replicated sites from the meQTL analysis; meta-analysed results (N = 1339)

From: Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics

    

Model 1

Model 2

Trait

CpG

Position (hg19)

Gene

β

SE

P

β

SE

P

COPD

cg18825076

78729989

IREB2

−5.165

2.514

0.04

−3.65

2.58

0.158

 

cg04882995

78912658

CHRNA3

1.6

3.098

0.606

−0.57

3.225

0.86

 

cg21242079

79101063

ADAMTS7

2.321

1.354

0.086

2.454

1.389

0.077

 

cg00540400

79124168

ADAMTS7-MORF4L1

2.577

1.27

0.042

3.228

1.313

0.014

 

cg04140906

78833505

PSMA4

−5.674

2.714

0.037

−6

2.772

0.03

 

cg05786009

79152474

ADAMTS7-MORF4L1

2.043

4.307

0.635

1.723

4.469

0.7

 

cg20117256

78726576

IREB2

−1.227

1.188

0.302

−1.54

1.23

0.212

 

cg16751781

78858589

CHRNA5

0.891

3.57

0.803

2.092

3.707

0.573

 

cg08701566

78911099

CHRNA3

6.785

3.971

0.087

6.333

4.136

0.126

 

cg13561554

78795944

IREB2-HYKK

−1.185

1.521

0.436

−0.62

1.559

0.689

  1. Model 1 adjusted for age, sex, technical covariates and different white blood cellular proportions; model 2 additionally adjusted for current smoking and pack-years; nominally significant results are shown in bold
  2. β coefficient estimates from the logistic regression models, P P-value of the significance
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