Fig. 3 | European Journal of Human Genetics

Fig. 3

From: Are your covariates under control? How normalization can re-introduce covariate effects

Fig. 3

The effect of applying a rank-based INT to questionnaire-type data before regressing out covariates. All correlations referred to in this figure are Pearson (linear) correlations. a Untransformed questionnaire-type variable and its relationship with a continuous covariate. The questionnaire-type variable has a range of 5. A weak linear relationship exists between the questionnaire-type variable and covariate. b Questionnaire-type variable after rank-based INT, randomly splitting tied observations. Relationship between the questionnaire-type variable remains intact. c Covariate effects have been regressed from the normalized questionnaire-type variable. There is no linear relationship between the residuals and the covariate, and the skew is close to zero

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