Table 1 Summary of attributes and levels used in the DCE survey
Test attribute | Possible levels for each testing alternative | |||
|---|---|---|---|---|
Whole genome sequencing | Whole exome sequencing | Cardiac panel test | Genetic testing not indicated | |
Ability of the test to identify pathogenic mutations | Pathogenic mutation is identified in 20 out of every 100 cases | Pathogenic mutation is identified in 0 out of every 100 cases | ||
Pathogenic mutation is identified in 30 out of every 100 cases | ||||
Pathogenic mutation is identified in 40 out of every 100 cases | ||||
Pathogenic mutation is identified in 50 out of every 100 cases | ||||
Ability of the test to identify variants of unknown significance | Variant of unknown significance is identified in 10 out of every 100 cases | Variant of unknown significance is identified in 0 out of every 100 cases | ||
Variant of unknown significance is identified in 20 out of every 100 cases | ||||
Variant of unknown significance is identified in 30 out of every 100 cases | ||||
Test cost | £1000 | £500 | £150 | £0 |
£3000 | £1500 | £300 | ||
£5000 | £2500 | £450 | ||
£7000 | £3500 | £600 | ||
Quantity of counselling received | 40 min | 40 min | 10 min | 0 min |
50 min | 50 min | 20 min | ||
60 min | 60 min | 30 min | ||
Disclosure of secondary findings | No secondary findings disclosed | No secondary findings disclosed | ||
Subset of well-characterised secondary findings disclosed | ||||
