Table 1 General information and phenotypic characteristic of sporadic deafness patients and normal hearing controls
Sporadic patients | Controls | ||
|---|---|---|---|
Characteristic | number | percentage of the total | number |
Sex | |||
Male | 232 | 53.58% | 345 |
Female | 201 | 47.42% | 271 |
Age when DNA samples collected | |||
Average | 10.55 | 31.18 | |
Age ≤ 2 | 73 | 16.86% | |
Age 3–17 | 259 | 59.82% | |
Age ≥ 18 | 101 | 23.32% | 616 |
Ethnicity | |||
Han | 415 | 95.84% | 616 |
Hui | 3 | 0.92% | |
Man | 9 | 2.08% | |
Dai | 1 | 0.23% | |
Mongolia | 3 | 0.69% | |
Zhuang | 1 | 0.23% | |
Xibo | 1 | 0.23% | |
Family history | |||
No Deafness family history | 407 | 94.00% | |
Report deafness family history | 14 | 3.23% | |
Ambiguous | 12 | 2.77% | |
Report use of ototoxic drugs | 7 | 1.62% | |
Onset of hearing loss | |||
Congenital | 317 | 73.21% | |
Childhood | 101 | 23.33% | |
Adult | 3 | 0.69% | |
Ambiguous | 12 | 2.77% | |
Severity | |||
Normal | 616 | ||
Mild-moderate | 13 | 3.00% | |
Severe-profound | 408 | 94.23% | |
Without audiogram | 12 | 2.77% | |
Laterality | |||
Bilateral | 432 | 99.77% | |
Unilateral | 1 | 0.23% | |
Syndromic hearing loss | 3 | 0.69% | |
Nonsyndromic hearing loss | 430 | 99.31% | |
Temporal bone computed tomography | |||
Bilateral enlarged vestibular aqueduct | 89 | 20.55% | |
Other inner ear malformation | 11 | 2.54% | |
Normal | 333 | 76.91% | |
Physical examination | |||
Microtia | 2 | 0.46% | |
Goiter | 1 | 0.23% | |
Heterochromia iridis | 2 | 0.46% | |
Cutaneous pigmentation | 2 | 0.46% | |
Ocular hypertelorism | 1 | 0.23% | |
Cochlear implantation | 121 | 27.94% | |
