Table 1 Empirical, sample-size dependent significance thresholds (α, with control of the FWER at 5%) for simulated genome-wide studies.
From: The exhaustive genomic scan approach, with an application to rare-variant association analysis
Sample size | Number of replications | SMA | GECS, 3 MAFT combined | GECS, MAFT = 0.01 | GECS, MAFT = 0.03 | GECS, MAFT = 0.05 |
|---|---|---|---|---|---|---|
1000 | 1000 | 2.95 × 10−8 | 7.35 × 10−10 | 3.61 × 10−9 | 1.73 × 10−9 | 1.60 × 10−9 |
5000 | 1000 | 1.86 × 10−8 | 3.31 × 10−10 | 1.26 × 10−9 | 8.92 × 10−10 | 8.49 × 10−10 |
10,000 | 1000 | 1.27 × 10−8 | 2.81 × 10−10 | 1.05 × 10−9 | 7.13 × 10−10 | 6.91 × 10−10 |
20,000 | 500 | 1.15 × 10−8 | 2.59 × 10−10 | 9.28 × 10−10 | 6.36 × 10−10 | 6.01 × 10−10 |
