Table 2 Top variants in loci associated with CAA formation with p < 5 × 10−6.

From: Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease

SNV

Chr

Positiona

Gene region

Allele

Alt. allele frequencies

  

Ref

Alt

CAA (+)

CAA (−)

OR (95% CI)

p

rs6017006

20

41934620

Intergenic

G

A

0.13

0.04

5.0 (2.8–9.0)

2.3 × 10−8

rs7871579

9

139990530

MAN1B1 intron

T

C

0.26

0.15

2.8 (1.8–4.2)

4.6 × 10−7

rs2449565

5

169135662

DOCK2 intron

A

G

0.75

0.61

2.3 (1.6–3.3)

1.9 × 10−6

rs10762437

10

73058469

UNC5B intron

A

G

0.25

0.16

2.5 (1.7–3.8)

3.5 × 10−6

rs35932034

3

106262305

Intergenic

T

C

0.03

0.11

0.2 (0.09–0.4)

3.7 × 10−6

rs1989051

8

129294118

Intergenic

T

C

0.69

0.57

2.2 (1.6–3.1)

4.0 × 10−6

  1. ORs were calculated using a Wald test, and p values were calculated using a Score test. All effects are relative to the alternate allele, ref/alt alleles are defined by the HRC reference panel.
  2. Chr. chromosome, CAA coronary artery aneurysm, OR odds ratio.
  3. aGRCh37/hg19 position.
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