Fig. 1: Experimental and analysis pipeline used to identify potential causative variants in reported genes associated with nonsyndromic and syndromic forms of hearing loss. | European Journal of Human Genetics

Fig. 1: Experimental and analysis pipeline used to identify potential causative variants in reported genes associated with nonsyndromic and syndromic forms of hearing loss.

From: Genomic analysis of childhood hearing loss in the Yoruba population of Nigeria

Fig. 1: Experimental and analysis pipeline used to identify potential causative variants in reported genes associated with nonsyndromic and syndromic forms of hearing loss.

Diagram shows the experimental strategy used for processing and analyzing the samples and data. Sanger sequencing was done on the gDNA of both parents if they had HL or on the gDNA of the proband with HL otherwise, for a total of 60 independent cases of HL. Variant counts are shown for the initial steps. The lists of genes included for these analyses are presented in Supplementary Information 2 and 3. *Full penetrance of HL was assumed unless reported otherwise for some genes associated with syndromic forms of HL. STRP short tandem repeat polymorphisms.

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