Table 3 Associations between PRSs and MM risk with the different types of scores.

Type of score	Quintiles	OR^a	95% CI^a	p_value
Unweighted, subjects with 100% call rate	1	1.00	–	Ref.
	2	0.63	0.46–0.86	0.004
	3	3.16	2.31–4.31	4.33 × 10⁻¹³
	4	2.42	1.81–3.24	3.17 × 10⁻⁹
	5	3.18	2.34–4.33	1.62 × 10⁻¹³
	Continuous^b	1.43	1.34–1.54	7.00 × 10⁻²³
Unweighted scaled, all subjects	1	1.00	–	Ref.
	2	1.52	1.17–1.97	0.002
	3	1.44	1.13–1.83	0.003
	4	2.20	1.73–2.80	1.45 × 10⁻¹⁰
	5	2.93	2.28–3.78	9.00 × 10⁻¹⁶
	Continuous^b	1.29	1.22–1.37	1.00 × 10⁻¹⁷
Weighted, subjects with 100% call rate^c	1	1.00	–	Ref.
	2	1.33	0.95–1.86	0.096
	3	1.60	1.15–2.23	0.005
	4	2.43	1.77–3.35	4.78 × 10⁻⁸
	5	3.44	2.53–4.69	3.55 × 10⁻¹⁵
	Continuous^b	1.37	1.28–1.46	2.00 × 10⁻¹⁸
Weighted scaled, all subjects^c	1	1.00	–	Ref.
	2	1.29	0.98–1.70	0.068
	3	1.53	1.17–2.01	0.002
	4	2.24	1.72–2.91	1.68 × 10⁻⁹
	5	3.12	2.42–4.02	2.00 × 10⁻¹⁷
	Continuous^b	1.33	1.26–1.41	3.00 × 10⁻²²
Weighted 100% call rate using GWAS OR^d	1	1.00	–	Ref.
	2	1.18	0.84–1.65	0.334
	3	1.56	1.12–2.17	0.008
	4	2.17	1.59–2.97	1.29 × 10⁻⁶
	5	3.24	2.39–4.39	3.93 × 10⁻¹⁴
	Continuous^b	1.35	1.27–1.45	2.00 × 10⁻¹⁷
Weighted scaled using GWAS OR^d	1	1.00	–	Ref.
	2	1.21	0.93–1.60	0.161
	3	1.56	1.20–2.04	0.001
	4	2.02	1.57–2.62	7.86 × 10⁻⁸
	5	2.89	2.25–3.71	9.00 × 10⁻¹⁶
	Continuous^b	1.31	1.24–1.38	9.00 × 10⁻²⁰

^aOR odds ratio; CI confidence interval; all analyses were adjusted for age, sex and geographic region of origin.
^bThe unit for the analysis with the continuous variable was the increment of one quintile.
^cThe weights used to build this score were the ORs of the associations between the individual SNPs and MM risk observed in the IMMEnSE population.
^dThe weights used to build this score were the ORs of the associations between the individual SNPs and MM risk observed in the literature.

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