Table 2 External validation of PRS models in European populations using data from UK Biobank and CIMBA.
From: Polygenic risk modeling for prediction of epithelial ovarian cancer risk
Model (data set) | SNPs | UK Biobank | CIMBA BRCA1 carriersa | CIMBA BRCA2 carriersa | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
AUC | OR | 95% CI | AUC | HR | 95% CI | AUC | HR | 95% CI | |||
(a) PRS models based on OCAC data | |||||||||||
Lasso (OCAC) | 1403 | 0.587 | 1.37 | 1.27–1.48 | 0.573 | 1.27 | 1.21–1.34 | 0.627 | 1.48 | 1.33–1.63 | |
Elastic net (OCAC) | 10,797 | 0.588 | 1.36 | 1.26–1.47 | 0.583 | 1.32 | 1.26–1.39 | 0.617 | 1.47 | 1.33–1.63 | |
Stepwise (OCAC) | 22 | 0.588 | 1.35 | 1.26–1.46 | 0.563 | 1.21 | 1.16–1.26 | 0.605 | 1.39 | 1.26–1.54 | |
Select and shrink (OCAC) | 27,240 | 0.588 | 1.38 | 1.28–1.48 | 0.592 | 1.36 | 1.29–1.43 | 0.624 | 1.49 | 1.35–1.64 | |
(b) PRS models based on meta-analysis of OCAC and CIMBA data | |||||||||||
Stepwise (OCAC-CIMBA)b | 36 | 0.595 | 1.39 | 1.29–1.50 | NA | NA | NA | NA | NA | NA | |
Select and shrink (OCAC-CIMBA) | 18,007 | 0.596 | 1.42 | 1.32–1.54 | NA | NA | NA | NA | NA | NA | |
