Table 2 Linkage analysis regions with LOD-score ≥ 3.3.
Pedigree | Chromosome | Position | Locus | Statistic | Highest NPL | Previous evidence |
|---|---|---|---|---|---|---|
1 | 2 | 150020329– 159204593 | 2q23.3–24.1 | Srobdom | 7.34 | Hypertension linkage analyses. IA GWAS |
2 | 217211217– 218756117 | 2q35 | Spairs and Srobdom | 7.48 | ||
9 | 93471627– 101092018 | 9q22.2–22.33 | Srobdom | 7.24 | Thoracid aortic aneurysm/Loeys Dietz syndrome, coronary artery disease, IA. | |
2 | 9 | 24756027– 25973292 | 9p21.3–21.2 | Srobdom | 6.00 | Near, but > 2 megabases away, the 9p GWAS locus associated with many cardiac traits |
10 | 72515775– 77216955 | 10q22.1–22.2 | Srobdom | 6.92 | Thoracic aortic aneurysm (ACTA2) | |
14 | 28788618– 34682723 | 14q12–13.1 | Srobdom | 6.73 | ||
3 | 5 | 81207272– 90645137 | 5q14.2–14.3 | Srobdom | 5.15 | IA (Exome sequencing study, EDIL3) |
5 | 171960073– 174241185 | 5q35.1–35.2 | Srobdom | 5.21 | ||
6 | 84533341– 94104527 | 6q14.2–16.1 | Srobdom | 4.40 | 3 megabases away from IA GWAS locus | |
7 | 36588659– 39942647 | 7p14.2–14.1 | Srobdom | 5.26 | ||
20 | 53425217– 54482619 | 20q13.2 | Srobdom | 5.28 | ||
22 | 48258293– 51151350 | 22q13.31-13.33 | Srobdom | 5.37 |
