Fig. 4: Basic science approaches.
From: The 2019 and 2021 International Workshops on Alport Syndrome
In the upper panel are summarised the new studies and approaches on podocytes, GEC and GBM ranging from CRISPR/Cas9 application to miRs that stimulate podocyte biology, proteomics and chaperones in combination with studies on podocytes cytoskeleton. In the lower panel the downstream applications of these: imagine technology, organoids in 3D culture, glomerulus on a chip to mimic the glomerular structure in vitro, and preclinical animal model testing in dog and mice.
