Table 1 Characteristics of the UK Biobank cohort.

From: Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank

 

White British

White European

South Asian

African-Caribbean

Mixed ancestry

N (% male)

402,820 (46.0)

50,510 (43.8)

7726 (53.9)

7644 (43.0)

10,447 (42.8)

Age (years)

56.9 (8.0)

55.6 (8.1)

53.4 (8.5)

51.9 (8.1)

52.4 (8.1)

BMI (KG/m2)

27.4 (4.8)

27.2 (4.9)

27.3 (4.5)

29.5 (5.4)

27.0(4.9)

WHR

0.87 (0.09)

0.9 (0.09)

0.9 (0.09)

0.9 (0.1)

0.9(0.1)

SBP (mmHg)

138 (19)

135.5 (18.5)

134.9 (18.6)

137.8 (18.7)

133.4 (18.6)

DBP (mmHg)

82 (10)

81.5 (10.2)

82.5 (10.2)

84.5 (10.7)

81.9 (10.5)

SBPa (mmHg)

141 (21)

138.2 (20.5)

139.1 (21.4)

142.5 (21.7)

136.4(21.0)

DBPa (mmHg)

84 (11)

83.3 (11.3)

85.2 (11.5)

87.7 (12.4)

83.9 (11.9)

Current smoking

40,618 (10.1)

6597 (13.1)

687 (8.9)

952 (12.5)

1437 (13.8)

Hypertension

205,846 (51.1)

22,787 (45.1)

3832 (49.6)

4321 (56.5)

4523(43.3)

Anti-hypertensive medication

83,951 (21.0)

9235(18.3)

2082 (26.9)

2340 (30.6)

2048(19.6)

Lipid-lowering medication

70,184 (20.6)

8042 (15.9)

2049 (26.5)

1212 (15.9)

1807(17.3)

PGS4

1.39 (0.97)

    

PGS7

3.88 (1.52)

    

ISH

18,383 (6.1)

2135 (4.2)

575 (7.4)

264 (3.5)

414 (4.0)

Stroke

6150 (2.1)

708 (1.4)

128 (1.7)

118 (1.5)

94 (0.9)

VTE

10,444 (3.7)

1239 (2.5)

131 (1.7)

185 (2.4)

189 (1.8)

T2D

17,420 (4.3)

2121 (4.2)

1288 (16.7)

812 (10.6)

865 (8.3)

Anhedonia

78,879 (19.6)

11,255 (22.3)

2813 (36.4)

2389 (31.3)

3336 (31.9)

Mood instability

177,994 (45.2)

22,089 (43.7)

2778 (48.9)

3724 (48.7)

4754 (45.5)

neuroticism score

1.65 (5.90)

1.39 (6.11)

−0.73 (7.06)

−0.25 (6.44)

−0.28 (6.79)

Risk-taking

98,435 (25.3)

16,240 (32.2)

2688 (34.8)

2986 (39.1)

3705 (35.5)

Mental Health questionnaire

130,370 (32.4)

16,751 (33.2)

1043 (13.5)

1104 (14.4)

2277 (21.8)

Addictionb

7471 (5.7)

1280 (2.5)

46 (0.6)

64 (0.8)

167 (1.6)

GADb

9096 (10.1)

1282 (2.5)

74 (1.0)

54 (0.7)

167 (1.6)

BDb

1873 (1.5)

324 (0.6)

24(0.3)

24 (0.3)

51 (0.5)

MDDb

30,875 (28.1)

4186 (8.3)

196 (2.5)

203 (2.7)

539 (5.2)

  1. Continuous variables are presented as mean (se), binary variables are presented as N (%).
  2. WHR Waist: hip ratio, PGS4 Polygenic score including four SNPs as per Schmidt et al, PGS7 Polygenic score including seven SNPs as per Ference et al, ISH Ischemic heart disease, VTE Venous thromboembolism, T2D type 2 diabetes.
  3. aadjusted for use of anti-hypertensive medication, as per Ehret et al.
  4. bof those who completed the mental health questionnaire.
Back to article page