Table 3 Lookup of lead SNPs in a published meta-analysis of PCSK9 protein levels.

From: Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank

  

UKB

Meta-analysis of PCSK9 levels

Phenotype

SNP

A1

A2

MAF

BETA

OR

EA

NEA

EAF

BETA_a

P_a

I2_a

BETA_b

P_b

I2_b

SBPadj

rs2647282

A

C

0.36

−0.196

 

A

C

0.37

−0.011

3.63E-02

0.57

−0.010

3.17E-02

0.55

WHRadjBMI

rs7543163

C

T

0.39

0.001

 

T

C

0.63

0.019

6.03E-04

0.80

0.020

4.54E-05

0.89

VTE (Lead)

rs746952505

CA

C

0.24

 

1.07

         

VTE (Proxy)

rs12071742

A

G

0.12

 

1.09

A

G

0.13

0.002

7.65E-01

0.31

0.006

3.14E-01

0.24

Stroke

rs72662600

G

A

0.08

 

0.86

         

Mood instability

rs11206514

C

A

0.39

 

1.02

A

C

0.62

0.019

3.32E-04

0.77

0.020

2.35E-05

0.88

Neuroticism Score

rs12069079

G

A

0.20

0.045

 

G

A

0.19

−0.006

3.20E-01

0.80

−0.007

1.72E-01

0.80

  1. Bold text indicates nominal significance (p < 0.05). Meta-analysis PMID: 34590679
  2. A1 Effect or minor allele, A2 Non-effect allele, MAF Effect or minor allele frequency, EA Effect allele, NEA Non-effect allele, EAF Effect allele frequency, a in individiauls not treated with statins (n = 10186), b in all individuals, with adjustment for statin use (n = 12,721), I2 Measure of heterogenity across cohorts included in the meta-analysis.
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