Table 4 Genotype-specific gene expression of trait-associated SNPs or proxies (LD R2 > = 0.50).
Trait | Lead SNP | Proxy SNP | Position | R2 | D' | Gene | Tissue | EAF | Effect | P value |
|---|---|---|---|---|---|---|---|---|---|---|
SBP | rs2647282 | 55,724,437 | MROH7 | Esophagus-Mucosa | A = 0.324 | −0.119 | 1.11E-04 | |||
USP24 | Heart-Atrial Appendage | A = 0.324 | −0.139 | 3.08E-06 | ||||||
USP24 | Muscle-Skeletal | A = 0.324 | −0.080 | 9.75E-06 | ||||||
USP24 | Nerve-Tibial | A = 0.324 | −0.093 | 1.43E-04 | ||||||
USP24 | Skin-Sun Exposed (Lower leg) | A = 0.324 | −0.115 | 5.28E-07 | ||||||
USP24 | Skin-Not Sun Exposed (Suprapubic) | A = 0.324 | −0.185 | 2.44E-11 | ||||||
WHRadjBMI | rs7543163 | rs11206513 | 55,507,649 | 0.915 | 1.000 | DHCR24 | Brain-Cortex | T = 0.544 | 0.129 | 5.06E-05 |
rs11206514 | 55,516,004 | 1.000 | 1.000 | DHCR24 | Brain-Cortex | A = 0.566 | 0.128 | 4.83E-05 | ||
rs11436234 | 55,511,623 | 0.893 | 0.977 | DHCR24 | Brain-Cortex | TC = 0.549 | 0.136 | 2.47E-05 | ||
rs7530425 | 55,511,471 | 0.915 | 1.000 | DHCR24 | Brain-Cortex | T = 0.544 | 0.136 | 2.47E-05 | ||
rs10888896 | 55,509,213 | 0.579 | 1.000 | PCSK9 | Adipose-Visceral (Omentum) | C = 0.692 | −0.277 | 2.66E-05 | ||
rs10888898 | 55,516,508 | 0.978 | 1.000 | PCSK9 | Skin-Not Sun Exposed (Suprapubic) | G = 0.56 | −0.138 | 9.28E-05 | ||
rs2479410 | 55,505,861 | 0.619 | 0.814 | PCSK9 | Brain-Cerebellum | A = 0.418 | −0.369 | 9.61E-05 | ||
PCSK9 | Skin-Not Sun Exposed (Suprapubic) | A = 0.418 | 0.162 | 1.73E-05 | ||||||
rs644000 | 55,511,995 | 0.694 | 0.902 | PCSK9 | Skin-Not Sun Exposed (Suprapubic) | G = 0.396 | 0.152 | 4.58E-05 | ||
rs6681159 | 55,507,882 | 0.579 | 1.000 | PCSK9 | Adipose-Visceral (Omentum) | T = 0.692 | −0.255 | 5.79E-05 | ||
rs7543163 | 55,515,481 | 1.000 | 1.000 | USP24 | Heart-Atrial Appendage | T = 0.566 | 0.116 | 8.22E-05 |
