Table 1 GWAS loci in COVID-19.
From: Host genetic basis of COVID-19: from methodologies to genes
Locus | chr:pos (hg38) | REF | ALT | rs | OR | Consequence | Genes | References |
|---|---|---|---|---|---|---|---|---|
1 | 1:155066988 | C | T* | rs114301457 | 2.40 | Synonymous | EFNA4 | |
2 | 1:155175305 | G | A* | rs7528026 | 1.39 | Intron | TRIM46 | |
3 | 1:155197995 | A* | G | rs41264915 | 1.20 | Intron | THBS3 | |
4 | 2:60480453 | A* | G | rs1123573 | 1.13 | Intron | BCL11A | |
5 | 3:101705614 | T* | C | rs11919389 | 1.02 | Downstream | ZBTB11, RPL24, CEP97, NXPE3 | [6] |
6 | 3:146517122 | G | A* | rs343320 | 1.25 | Missense | PLSCR1 | |
7 | 3:45796521 | G | T* | rs2271616 | 1.26 | 5’UTR | SLC6A20 | |
| Â | 3:45823240 | T | C* | rs10490770 | 1.88 | Downstream | LZTLF1 | [6] |
| Â | 3:45834968 | AA | AAA* | rs11385942 | 1.77 | Intron | SLC6A20, LZTFL1, FYCO1, CXCR6, XCR1, and CCR9. | [4] |
| Â | 3:45859597 | C | T* | rs73064425 | 2.71 | Intron | LZTLF1 | |
8 | 5:131995059 | C | T* | rs56162149 | 1.20 | Intron | ACSL6 | |
9 | 5:132441275 | T | C* | rs10066378 | 1.20 | Intron | IRF1-AS1 | [7] |
10 | 6:41534945 | A | C* | rs1886814 | 6.17 | eQTL, Intron | FOXP4 | |
11 | 6:29831017 | A* | G | rs9380142 | 1.3 | 3’UTR | HLA-G | [5] |
12 | 6: 32180146 | A | G* | rs3131294 | 1.1 | Intron | NOTCH4 | [5] |
13 | 6:32623820 | T* | C | rs9271609 | 1.14 | Upstream | HLA-DQA1 | [7] |
14 | 6:41515007 | A* | C | rs2496644 | 1.45 | Intron | LINC01276 | [7] |
15 | 8:124324323 | T | C* | rs72711165 | 1.227 | Intron | TMEM65 | [6] |
16 | 9:133257521 | A | C* | rs657152 | 1.32 | Intron | ABO | [4] |
| Â | 9:133274084 | C* | T | rs912805253 | 1.14 | eQTL, Intron | ABO | |
17 | 11:34482745 | G* | A | rs61882275 | 1.27 | Intron | ELF5 | |
18 | 9:21206606 | C | G* | rs28368148 | 1.45 | Missense | IFNA10 | [7] |
19 | 12:113363550 | C | T* | rs6489867 | 1.3 | Intron | OAS1–OAS3 | [5] |
|  | 12:112919388 | G | A* | rs10774671 | 1.2 | eQTL, Splice Acceptor Variant | OAS1–OAS3 | |
|  | 12:113380008 | G | A* | rs10735079 | 1.3 | Intron | OAS1–OAS3 | [5] |
20 | 12:132489230 | GC | G* | rs56106917 | 1.13 | eQTL, Upstream | FBRSL1 | |
| Â | 12:132479205 | G | A* | rs4883585 | 1.13 | Upstream | FBRSL1 | [7] |
21 | 13:112889041 | C | T* | rs9577175 | 1.18 | Downstream | ATP11A | |
22 | 15:93046840 | T* | A | rs4424872 | 1.04 | Intron | RGMA | |
23 | 16:89196249 | G* | A | rs117169628 | 1.18 | eQTL, Missense | SLC22A31 | [7] |
24 | 17:46142465 | T* | A | rs1819040 | 1.1 | eQTL, Intron | ARHGAP27, PLEKHM1, LINC02210-CRHR1, CRHR1, SPPL2C, MAPT, STH, KANSL1, LRRC37A, ARL17B, LRRC37A2, ARL17A, NSF, WNT3 | |
25 | 17:49863260 | C | A* | rs3848456 | 1.50 | regulatory | – | |
26 | 17:49863303 | C | T* | rs77534576 | 1.45 | Downstream | KAT7, TAC4 | [6] |
27 | 19:10466123 | T | C* | rs11085727 | 1.3 | eQTL, Intron | TYK2 | |
| Â | 19:10317045 | T | A* | rs74956615 | 1.6 | eQTL, Downstream | ICAM1, ICAM4, ICAM5, ZGLP1, FDX2, RAVER1, ICAM3, TYK2 | |
| Â | 19:10352442 | G* | C | rs34536443 | 1.5 | eQTL, Missense | TYK2 | |
| Â | 19:10305768 | G | A* | rs73510898 | 1.24 | eQTL, Intron | ZGLP1 | |
28 | 19:4719431 | A | G* | rs2109069 | 1.4 | Intron | DPP9 | [5] |
| Â | 19:4717660 | A | G* | rs12610495 | 1.3 | Intron | DPP9 | |
29 | 19:48697960 | C | T* | rs368565 | 1.15 | eQTL, Intron | FUT2 | |
30 | 19:48867352 | G* | T | rs4801778 | 1.1 | Intron | PLEKHA4, PPP1R15A, TULP2, NUCB1 | [6] |
31 | 21:33230000 | C | A* | rs17860115 | 1.24 | eQTL, 5’UTR | IFNAR2 | |
| Â | 21:33242905 | T* | C | rs13050728 | 1.23 | eQTL, Intron | IFNAR2 | |
32 | 21:33287378 | C | T* | rs8178521 | 1.18 | eQTL, Intron | IL10RB | |
33 | 21:33959662 | T | TAC* | rs35370143 | 1.26 | Intron | LINC00649 | |
| Â | 21:33914436 | A | G* | rs12626438 | 1.22 | Intron | LINC00649 | [7] |