Table 1 Genome-wide significant associations with acne vulgaris.
From: Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris
Chr | Pos (GRCh37) | RA | PA | rsID | Band | RA Freq | OR (95% CI) | P value | Gene region |
|---|---|---|---|---|---|---|---|---|---|
1 | 8207579 | C | G | rs80293268 | 1p36.23 | 0.080 | 1.17 (1.13–1.21) | 2.10 × 10−17 | ERRFI1-(SLC45A1) |
1 | 183166970 | T | C | rs3118181 | 1q25.3 | 0.509 | 1.06 (1.04–1.08) | 3.08 × 10−10 | LAMC2 |
1 | 202358947 | T | C | rs2696958 | 1q32.1 | 0.499 | 1.06 (1.04–1.08) | 1.93 × 10−10 | PPP1R12B-UBE2T-LGR6 |
1 | 218858745 | A | G | rs1481362 | 1q41 | 0.418 | 1.10 (1.08–1.12) | 5.33 × 10−22 | TGFB2 |
1 | 219199380 | C | G | rs1256580 | 1q41 | 0.141 | 1.11 (1.08–1.14) | 2.71 × 10−15 | LYPLAL1-DT |
2 | 60520351 | T | A | rs9808396 | 2p16.1 | 0.443 | 1.06 (1.04–1.08) | 7.88 × 10−10 | BCL11A |
3 | 12030034 | T | C | rs2600262 | 3p25.2 | 0.787 | 1.07 (1.04–1.09) | 1.57 × 10−8 | TIMP4-PPARG |
5 | 44362134 | C | T | rs10941664 | 5p12 | 0.714 | 1.06 (1.04–1.08) | 2.18 × 10−8 | FGF10 |
5 | 52628130 | C | T | rs37776 | 5q11.2 | 0.354 | 1.10 (1.08–1.12) | 1.04 × 10−20 | ITGA1-ITGA2-MOCS2-FST |
5 | 55596919 | A | G | rs185094 | 5q11.2 | 0.068 | 1.11 (1.07–1.15) | 4.01 × 10−8 | ANKRD55 |
5 | 131797578 | T | C | rs2522051 | 5q31.1 | 0.458 | 1.05 (1.04–1.07) | 1.59 × 10−8 | SLC22A5-IRF1-IL5-(RAD50) |
11 | 13130559 | T | C | rs11022666 | 11p15.3 | 0.349 | 1.08 (1.06–1.10) | 3.19 × 10−15 | RASSF10-ARNTL |
11 | 61619829 | C | A | rs174594 | 11q12.2 | 0.379 | 1.08 (1.06–1.10) | 4.45 × 10−14 | FADS1-FADS2 |
11 | 64611543 | C | T | rs11231890 | 11q13.1 | 0.797 | 1.08 (1.06–1.11) | 8.33 × 10−12 | CDC42BPG |
11 | 65521126 | G | T | rs11227289 | 11q13.1 | 0.438 | 1.06 (1.04–1.08) | 1.23 × 10−8 | OVOL1-MAP3K11 |
12 | 12604777 | A | G | rs10734852 | 12p13.2 | 0.538 | 1.07 (1.05–1.09) | 1.99 × 10−13 | BORCS5 |
12 | 71691648 | A | G | rs4760791 | 12q21.1 | 0.586 | 1.06 (1.04–1.08) | 1.14 × 10−9 | TSPAN8-LGR5 |
15 | 90734426 | C | T | rs34560261 | 15q26.1 | 0.839 | 1.16 (1.13–1.19) | 1.06 × 10−28 | SEMA4B |
16 | 11034933 | G | A | rs6498135 | 16p13.13 | 0.593 | 1.06 (1.04–1.08) | 7.39 × 10−9 | CIITA-DEXI-CLEC16A |
17 | 80117478 | C | A | rs8078102 | 17q25.3 | 0.242 | 1.07 (1.05–1.09) | 3.82 × 10−10 | FASN-CCDC57-SLC16A3 |
22 | 29453193 | G | C | rs12321 | 22q12.1 | 0.641 | 1.06 (1.04–1.08) | 1.15 × 10−8 | ZNRF3-C22orf31-KREMEN1 |
22 | 33221375 | G | A | rs130291 | 22q12.3 | 0.546 | 1.06 (1.04–1.08) | 7.83 × 10−10 | TIMP3 |
22 | 50321928 | C | T | rs7410766 | 22q13.33 | 0.215 | 1.07 (1.05–1.10) | 1.26 × 10−9 | ALG12-CRELD2-PIM3 |
