Fig. 1: Pedigree of a North American kindred, initially recruited as two independent families (probands PID V-1, VI-21) showing co-segregation of a novel pathogenic POU4F3 (c.37del) variant and autosomal dominant sensorineural hearing loss. | European Journal of Human Genetics

Fig. 1: Pedigree of a North American kindred, initially recruited as two independent families (probands PID V-1, VI-21) showing co-segregation of a novel pathogenic POU4F3 (c.37del) variant and autosomal dominant sensorineural hearing loss.

From: Highly variable hearing loss due to POU4F3 (c.37del) is revealed by longitudinal, frequency specific analyses

Fig. 1: Pedigree of a North American kindred, initially recruited as two independent families (probands PID V-1, VI-21) showing co-segregation of a novel pathogenic POU4F3 (c.37del) variant and autosomal dominant sensorineural hearing loss.The alt text for this image may have been generated using AI.

A Seven-generation pedigree with 38 direct descendants of the pedigree founders with hearing loss are marked with a black symbol. B Electropherogram of the novel POU4F3 c.37del frame-shifting variant (left panel, bottom) compared to reference sequence (left panel, top) and to an unaffected relative (right panel, bottom) compared to reference sequence (right panel, top). PID person ID in the pedigree.

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