Fig. 4: Comparison of age-related typical audiograms (ARTAs) across four DFNA15/POU4F3 pedigrees.

A ARTA for the North American kindred range from the 1st to 8th decade including all POU4F3 c.37del carriers (17 clinically affected including 3 with normal hearing). B ARTA for the 14 clinically affected c.37del carriers. C ARTA from a Dutch family with the L223P variant. D ARTA for a Dutch family with the L289F variant. E Israeli Jewish family with the 884del8 variant. All analyses are based on original threshold data without correction for presbycusis. ARTAs adapted from this figure (de Heer et al. [11]) with permission.