Fig. 2: Genomic location and methylation pattern for significantly altered CpGs in HNRNPU group. | European Journal of Human Genetics

Fig. 2: Genomic location and methylation pattern for significantly altered CpGs in HNRNPU group.

From: Germline pathogenic variants in HNRNPU are associated with alterations in blood methylome

Fig. 2: Genomic location and methylation pattern for significantly altered CpGs in HNRNPU group.

A total of 16 differentially methylated blocks (DMBs) including 10 CpG islands and 6 Open Sea regions were identified as significant among 7 HNRNPU patients. Based on methylation values, 12 DMBs were found to be hypermethylated (Island 2, 3, 4, 5, 6, 8, 10 and Open Sea 1, 2, 4, 5, 6) and 4 DMBs (Island 1, 7, 9 and Open Sea 3) were hypomethylated.

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